Curriculum Vitae

Richard Hosmer Merrill, MD

Personal

Office Address:
The Kidney Center, PA
990 Johns Hopkins Drive
Greenville, NC 27834

Date of Birth: November 13, 1940

Place of Birth: Pittsfield, Massachusetts


Education

1958-1962 Bachelor of Arts, Bowdoin College
Brunswick, Maine

1962-1966 Doctor of Medicine, Boston University School of Medicine
Boston, Massachusetts

1966-1967 Internal Medicine Internship, District of Columbia General Hospital
Washington, D.C.

1967-1970 Internal Medicine Residency, U.S. Army Tripler General Hospital
Honolulu, Hawaii

1970-1972 Nephrology Fellowship, Walter Reed Army Medical Center
Washington, D.C.

Professional Experience

9/72-6/74 Chief, Renal Section, U.S. Army Institute of Surgical Research
Fort Sam Houston, Texas

9/72-9/74 Chief, Hemodialysis Unit, Brook Army Medical Center
Fort Sam Houston, Texas

6/74 - 678 Chief, Nephrology Service, Brook Army Medical Center
Fort Sam Houston, Texas

6/74 - 1079 Chief, Internal Medicine Branch, U.S. Army Institute of Surgical Research
Fort Sam Houston, Texas

10/79 - 11/83 Associate Professor of Medicine, Chief, Renal Medicine, East Carolina University School of Medicine, Greenville, North Carolina

11/83 - 7/95 Associate Professor of Medicine, Renal Medicine, East Carolina University School of Medicine, Greenville, North Carolina

7/95 - 7/95 Professor of Medicine, Renal Medicine, East Carolina University School of Medicine, Greenville, North Carolina

8/95 - present Medical Director, The Kidney Center, PA
Greenville, North Carolina

Certification

7/67 National Board of Medical Examiners

3/71 American Board of Internal Medicine - Internal Medicine

10/72 American Board of Internal Medicine - Subspecialty: Nephrology

10/99 American Society of Hypertension - ASH Specialist Program
Specialist in Clinical Hypertension

Licensure

1970 Massachusetts
1971 Maryland
1975 Texas
1975 North Carolina

Professional Society Memberships

American Society of Hypertension
American Society of Nephrology
International Society of Nephrology
Renal Physicians Association
Fellow, American College of Physicians-American Society of Internal Medicine
American Heart Association
American Medical Association
North Carolina Medical Society
Pitt County Medical Society
Council on High Blood Pressure
Charter Member, Southeastern Hypertension Consortium
Private Physicians Association of Pitt County

Professional Service

1974 - 1979 Nephrology Consultant: Health Services Command

1975 - 1979 Reviewer: Dialysis and Transplantation

1975 - present Annals of Internal Medicine
Archives of Internal Medicine

Grants and Awards

Merrill, R.H. (Principal Investigator): A Double-Blind Comparison of Doxazosin and Hydrochlorothiazide in Patients with Mild to Moderate Hypertension. September 1, 1983 to August 31, 1984. Funded by Pfizer Labs. ($42,000)

Merrill, R.H. (Principal Investigator): Double-Blind, Randomized, Cross-Over Study to Compare Patient Preference for Enalapril vs. Atenolol in Mild to Moderate Hypertension and to Compare the Efficacy and Tolerability of Each Agent. August 16, 1984 to August 15, 1985. Funded by Merck, Sharp & Dohme Research Laboratories. ($6,969)

Merrill, R.H. (Principal Investigator): Evaluation of Labetalol (Trandate) in Hypertensive Patients Experiencing Unwanted Side Effects to Previous Beta-Blocker Therapy. August 1984 to August 1985. Funded by Glaxo Incorporated, Research Triangle Park. ($3,550)

Merrill, R.H. (Principal Investigator): Long Term Open Comparative Study of Doxazosin and Hydrochlorothiazide in Patients with Mild to Moderate Hypertension. January 1985 to January 1986. Funded by Pfizer Labs. ($60,562)

Merrill, R.H. (Principal Investigator): Evaluation of the Antihypertensive Effect of Lisinopril Plus HydralazIne Compared to Metoprolol Plus Hydrochlorothiazide Plus Hydralazine in Patients with Moderate to Severe Essential Hypertension. March 1, 1985 to March 1, 1986. Funded by Merck, Sharp & Dohme Research Laboratories. ($34,661)

Merrill, R.H. (Principal Investigator): Protocol for a Multicenter Determination of the Optimal Doses of Spirapril (T1 211-950) and Hydrochlorothiazide to be Used in Combination Administered Once-A-Day in the Treatment of Hypertension. September 1988 to September 1989. Funded by Sandoz Pharmaceuticals. ($40,000)

Merrill, R.H. (Principal Investigator): Antihypertensive Lipid Lowering Treatment to Prevent Hearth Attach Trial (ALLHAT). 1995 to present


Committees

Dialysis Care Committee
Renal Transplant Committee


Administrative Experience

9/72 -6/74 Chief, Renal Section, U.S. Army Institute of Surgical Research
Fort Sam Houston, Texas

9/72 - 974 Chief, Hemodialysis Unit, Brook Army Medical Center
Fort Sam Houston, Texas

6/74 - 678 Chief, Nephrology Service, Brook Army Medical Center
Fort Sam Houston, Texas

6/74 - 10/79 Chief, Internal Medicine Branch, U.S. Army Institute of Surgical Research
Fort Sam Houston, Texas

10/79 - 11/83 Chief, Renal Medicine, East Carolina University School of Medicine
Greenville, North Carolina

8/95 - present Medical Director, The Kidney Center
Greenville, North Carolina 27834


Teaching Experience

Continuing Education:
Eastern AHEC Lectures, 1979 - present

Guest Faculty:
Family Practice Refresher Course, March 12, 1980, Eastern AHEC, East Carolina University,
Greenville, North Carolina

Renal Disease, A Symposium. April 17, 1980, presented by the Craven-Pamlico-Jones Medical Society, New Bern, North Carolina

Current Clinical Problems in Family Practice, March 11, 1981, Eastern AHEC, East Carolina University, Greenville, North Carolina

The Fifth Annual Physicians Refresher Course, April 2-6, 1984, AHEC and Surgeon General's Office and Womack Army Hospital, Fayetteville, North Carolina

Alternatives to Dialysis, Annual Conference, May 11, 1984, Williamsburg, Virginia

Course Director:
Transplantation 1975, January 29-31, 1975, Blesse Auditorium, US Army Academy of Health Sciences, Fort Sam Houston, Texas

Selected Aspects of Chronic Renal Failure, January 28-30, 1976, Blesse Auditorium, US Army Academy of Health Sciences, Fort Sam Houston, Texas

Current Topics in Nephrology, 1977, American College of Physicians Course, San Antonio, Texas

Hypertension Update, October 11-13, 1978, Blesse Auditorium, US Army Academy of Health Sciences, Fort Sam Houston, Texas

Complications of Uremia, April 2-6, 1979, American College of Physicians Course, La Mansion Del Norte Hotel, San Antonio, Texas

Renal Dysfunction and Hypertensive Disorders in Pregnancy, December 3-4, 1982, East Carolina University School of Medicine, Greenville, North Carolina

Pregnancy and the Internist, February 27-March 2, 1984, American College of Physicians Course, Beaver Run, Breckenridge, Colorado

Pregnancy and the Internist, February 25-March 1, 1985, American College of Physicians Course, Beaver Run, Breckenridge, Colorado

Instructional Materials:
Films
Diet Therapy in Renal Failure, 1973
Initiating Hemodialysis, 1974
Team Approach to Hemodialysis, 1974
Acute Venous Unipuncture Dialysis, 1974
Dialysis Complications, 1974
Terminating Dialysis, 1974

Videotapes
Renal Biopsy, 1984
Hemodialysis, 1984
Percutaneous Renal Artery Angioplasty, 1984

Student Advising:
M-1 Advisor, 1982-1983

Research Activities and Interests

Approved Research Protocols
"Outpatient Percutaneous Renal Biopsy," (Approved: April, 1980)

"Immunologic Surveillance in End-Stage Renal Disease," (Approved: January, 1983)

"A Double-Blind Comparison of Doxazosin and Hydrocholorothiazide in Patients with Mild to Moderate Hypertension," (Approved: August, 1983)

"Long Term Open Comparative Study of Doxazosin and Hydrochlorothiazide in Patient with Mild to Moderate Hypertension," (Approved: April, 1984)

"A Double-Blind, Randomized, Crossover Study to Compare Patient Preference for Enalapril vs. Atenolol in Mild to Moderate Hypertension and to Compare the Efficacy and Tolerability of Each Agent," (approved: August, 1984)

"Evaluation of Labetalol (Trandate) in Hypertensive Patients Experiencing Unwanted Side Effects to Previous Beta-Blocker Therapy," (Approved: August, 1984)

"A Study of the Mechanisms of Pregnancy-Induced Hypertension," (Approved: October, 1984)

"Protocol for a Multicenter Determination of the Optimal Doses of Spirapril (T1 211-950) and Hydrochlorothiazide to be Used in Combination Administered Once-A-Day in the Treatment of Hypertension," (Approved: July, 1988)

Publications

In Refereed Journals:
Merrill RH. Diving Physiology and Decompression Illness. Mil Med 1970;135:464-470.

Martin CM, Merrill RH, Barrett Jr. O. Arthritis Due to Serratia. J Bone Joint Surg 1970;52A:1450-1452.

Merrill RH, Collins, JL. Acute Psychosis in Chronic Renal Failure. Mil Med 1974;139:622-624.

Merrill RH. Onycholysis, Fungal Versus Drug Induced. Southern Med J 1974;67:667-678.

Merrill RH, Baer HL. Use of Bason Test in Management of Heparin Therapy in Patients on Hemodialysis. Dialysis & Transplantation, April/May: 10-11, 1974.

Oettinger CW, Merrill RH, et al. Reduced Calcium Absorption after Nephrectomy in Uremic Patients. New England Journal of Medicine 1974;291:458-460.

Merrill RH, Barrett Jr. O. Positive Mono-Spot Test in Histiocytic Medullary Reticulosis. American Journal of Clinical Pathology 1976;65:(3):407-411.

Nash Jr. DA, Merrill RH. Kidney Transplantation in the Active Duty Soldier. Mil Med 1976; 141:No.8,545-546.

Merrill RH. Acute Venous Dialysis Utilizing the Unipuncture Apparatus. Amer J of Surg 1976;132:410-414 (September).

Merrill RH, Tasch R. Iron Absorption in Hemodialyzed Patients. The American Society for Artificial Organs, XXII 1976;5:53.

Merrill RH. Review of Vascular Access, Dialysis & Transplantation, December 22, 1976.

Merrill RH. Iron Metabolism in End-Stage Renal Disease. Dialysis & Transplantation, 1979;8:898-904 (September).

Merrill RH, McLeod CG, Jarstfer BS. The Use of Lyophilized Vein Grafts in Vascular Access for Chronic Hemodialysis. Artificial Organs 1979;3:245-248 (August).

Langlinais PC, Myers WP, Merrill RH. Scanning Electron Microscopic Observations of Glomeruli. Archives of Pathology and Laboratory Medicine 1980;104:308-312 (June).

Merrill RH, Raab SO. Dialysis Catheter-Induced Pericardial Tamponade. Archives of Internal Medicine 1982;142:1751-1753 (September).

Merrill RH. Dialysis Catheter-Induced Pericardial Tamponade. (Letter to the Editor) Archives of Internal Medicine 1983;143:181-182.

Merrill RH. Fatal Cardiac Tamponade. (Letter to the Editor) JAMA 1983;249(13):1707 (April).

Merrill RH, Dombroski R, MacKenna J. Primary Hyperaldosteronism During Pregnancy. American Journal of Obstetrics and Gynecology 1984;150:786-787 (November).

Merrill RH, Knupp CL, Jeanette JC. Familial Thrombotic Microangiopathy. Qtr. Journal of Medicine, New Series 1985;57;No. 223:749-759 (November).

Abdel-Rahman A-RA, Merrill RH, Wooles WR. Effect of Acute Ethanol Administration on the Baroreceptor Reflex Control of Heart Rate in Normotensive Human Volunteers. Clinical Science 1987;72:113-122 (January).

Zachariah PK, Bonnet G, Merrill RH, et al. Evaluation of Antihypertensive Efficacy of Lisinopril Compared to Metoprolol in Moderate to Severe Hypertension. Journal of Cardiovascular Pharmacology 1987;9(3):553-558.

Knupp CL, Merrill RH, Treadwell EL. Coombs Negative Spherocytic Hemolytic Anemia and Severe Necrotizing Renal Vasculitis. Southern Medical Journal 1988;81:259-262 (February).

Merrill RH. The Technique of Slow Continuous Ultrafiltration. Journal of Critical Illness 1991;6(3):289-294.

Merrill RH. Techniques of Continuous Arteriovenous Hemofiltration and Hemodialysis. Journal of Critical Illness 1991;6(4):381-387.

Abdel-Rahman A-RA, Merrill RH, Wooles WR. Sex-related Differences in the Baroreceptor Reflex Control of Heart Rate in Normotensive Humans. J Appl Physiol 1994;72(2):606-613.

Abstracts
Kem G, Burdick G, and Merrill R. Thiazide Administration in Hyperthyroidism. Clin Res 1970;18:457.

Myers WD, Langlinais PC, Merrill RH. Glomerular Alterations by Scanning Electron Microscopy in Acute Renal Insufficiency in Man. American Society of Nephrology, Tenth Annual Meeting. September, 1977.

Merrill RH, Solow R. Depressed Cellular Immunity in Patients with Chronic Renal Failure. American Society of Nephrology, Tenth Annual Meeting, September, 1977.

Merrill RH, Abdel-Rahman A-RA, Wooles R. Ethanol Impairs Human Baroreceptor Function. The American Society of Nephrology, December 9-12, 1984, Washington DC.

Merrill RH, Abdel-Rahman A-RA, Wooles R. Resetting of Baroreflex Sensitivity (BS) in Humans by Ethanol. Clinical Research, Vol 33, No 2, 1985.

Presentations

Arthritis Due to Serratia. Present Concepts in Iternal Medicine. Letterman Army Medical Center, San Francisco, California, November 4, 1969.

Arthritis due to Serratia. American College of Physicians. Hawaii Regional Meeting, February 17, 1070.

Use of Bason Test in Management of Heparin Therapy in patients on Hemodialysis. Southeastern Dialysis & Transplant Association Meeting. Little Rock, Arkansas, August 10, 1973.

Calcium Absorption in the Anephric State. American Society of Nephrology Meeting, Washington, DC, 1973.

Acute Venous Dialysis utilizing the Unipuncture Apparatus. Southeastern Dialysis & Transplant Association Meeting. Charleston, South Carolina, 1974.

Iron Absorption in Hemodialyzed Patients. Southeastern Dialysis & Transplant Association Meeting, Dallas, Texas, August, 1975.

Iron Absorption in Hemodialyzed Patients. American Society for Artificial Internal Organs National Meeting, San Franscisco, California, April 1-3, 1976.

Use of Lyophilized Homografts for Creation of AV Fistula. Southeastern Dialysis & Transplant Association Meeting, Nashville, Tennessee, August, 1976.

Glomerular Alterations by Scanning Electron Microscopy in Acute Renal Insufficiency in Man. Myers, WD, Langlinais PC, and Merrill RH. American Society of Nephrology, Tenth Annual Meeting, September, 1977.

Depressed Cellular Immunity in Patients with Chronic Renal Failure. American Society of Nephrology Meeting, Washington, DC, November, 1977.

Hematologic Impairment of End-Stage Renal Disease. Southeastern Dialysis & Transplant Association Meeting, New Orleans, Louisiana, August, 1979.

Element Analysis of Cell Populations Utilizing X-Ray Fluorescence Spectrometry. Bray JT, Waymer RC, Williams RT, Ryan PJ, Merrill RH. Fed of Analyt Chem and Spectroscopy Society, St. Louis, Missouri, September 28-October 3, 1986.

Renal Dysfunction and Hypertensive Disorders in Pregnancy. December 3 and 4, 1982. East Carolina University School of Medicine, Greenville, North Carolina

Polymorphonuclear Cell (PMN) Function in Patients on Continuous Ambulartory Peritoneal Dialysis (CAPD), National Kidney Foundation Meeting, Washington, DC, December, 1983.

Ethanol Impairs Human Baroreceptor Function. National Kidney Foundation Meeting, Washington, DC, December, 1984.

Pulsed Steroid Therapy in Acute Interstitial Nephritis. Drug-Induced Nephrotoxicity Symposium, Antwerp, Belgium, September 27 and 28, 1985.

Baroreceptor Resetting by Ethanol in Humans. American Society of Hypertension First Annual Meeting, Waldorf Astoria Hotel, New York, New York, May 28-31, 1986.

Sex as a Variable in Baroreflex Control of Heart Rate in Normotensive Humans. Fed. Amer. Society of Experimental Biology Meeting, Washington DC, March 29-April 2, 1987. (Published in Federation Proceedings Vol. 46, No. 3, March 1, 1987 #171, page 346.)


Exhibits:
Acute Renal insufficiency in Vietnam. American College of Physicians Meeting, Denver, Colorado, April. 1971.

Acute Renal Insufficiency in Vietnam. American Medical Association Meeting. Atlantic City, New Jersey, 1971 (Homorable Mention)

Acute Venous Unipuncture Dialysis. American College of Surgeons Meeting. Miami, Florida, October. 1974.

Acute Venous Unipuncture Dialysis. Accepted for American College fo Physicians Meeting. San Francisco, California, April. 1975 (Not sent due to lack of funding.)

Reviews:
Annals of Internal Medicine, Vol 113:1004, December, 1990. Clinical Hypertension. Fifth Edition Norman Kaplan Williams & Williams Ballisone

Community Service

Military History:
Regular Army, 1967-1979

Lieutenant Colonel, US Army, Date of Rank: May 29, 1975

Lieutenant Colonel, Medical Corps, US Army Reserve, 1980-1984

Colonel, Medical Corps, US Army Reserve, 1984-present

Commander, 350th MASH Unit, 1988-1990

US Power Squadron, 1980-present

Other Information

Grants Submitted:
"The Effect of Strict Blood Pressure Regulation on Fetal Outcome in Pregnancy-Induced Hypertension." Submitted to March of Dimes Birth Defects Foundation. August, 1983. Two year grant amount: $240,643.00

"Effect of Ethanol on Baroreflex Activity." Submitted to North Carolina Council of Alcoholism. August, 1983. Amount of grant: $30,400.00

"African American Study of Kidney Disease & Hypertension: Full Scale Trial" Submitted to NIH, January, 1994. Amount of grant: $2,276.896.00

"Morbidity and Mortality in Hemodialysis Study Protocol." Submitted to NIH-Division of Kidney, Urologic & Hemologic Diseases, March, 1994. Amount of grant $3,037,684.00